A Single-Cell Atlas of DNA Methylation in Autism Spectrum Disorder Reveals Distinct Regulatory and Aging Signatures

Collection Type
Dynamic
Keywords
snmCT-seq WGS ASD autism Age Aging DNA methylation RNA Single-nucleus BA9 Prefrontal Cortex PFC

"Autism spectrum disorder (ASD) is a prevalent and heterogeneous condition that profoundly impacts health and behavior. Analysis of gene expression in the cortex broadly implicates decreased synaptic functioning in excitatory neurons and increased reactivity in glia in ASD; however, whether these phenotypes are reflected in epigenetic signatures is unknown. Here, we report on the first single-cell analysis of DNA methylation (DNAm) in ASD. We profile DNAm from over 60,000 nuclei derived from 49 donors and interpret our findings with gene expression from the same nuclei using snmCT-seq."

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restricted
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CC BY 4.0

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  • Download BDBag https://data.nemoarchive.org/publication_release/Luo_scAtlas_of_DNA_methylation_in_Autism_Spectrum_Disorder-bag-2025-08-22.tgz 91,947 files 19,326.99 GB
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human

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Child collections

  • nemo:dat-j4sawn1
    A Single-Cell Atlas of DNA Methylation in Autism Spectrum Disorder Reveals Distinct Regulatory and Aging Signatures: Raw_WGS
  • nemo:dat-uzb0uf6
    A Single-Cell Atlas of DNA Methylation in Autism Spectrum Disorder Reveals Distinct Regulatory and Aging Signatures: Raw_snmCT-seq
  • nemo:dat-93iuq79
    A Single-Cell Atlas of DNA Methylation in Autism Spectrum Disorder Reveals Distinct Regulatory and Aging Signatures: Analysis_snmCT-seq

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