Glutamatergic Neuron Types in Layer 2 and Layer 3 of the Human Cortex: Human Patchseq L2/3 RNAseq
"Neurons can be classified on the basis of structural, physiological and/or genetic attributes. Using a method called Patch-seq, the electrophysiological, morphological, and transcriptomic features of individual cells can be simultaneously obtained. We characterized the morphological and physiological properties of five transcriptomically-defined human glutamatergic supragranular neuron types. Three of these types have properties that are specialized as compared to the more homogeneous properties of transcriptomically defined homologous mouse neuron types. The two remaining supragranular neuron types, located exclusively in deep layer 3, do not have clear mouse homologues in supragranular cortex but are transcriptionally most similar to deep layer mouse intratelencephalic-projecting neuron types."
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