Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon

Program
biccn
Collection Type
Static
Keywords
neural stem cell radial glial cell patterning center telencephalic organizer GALP development evolution neocortex neurogenesis gliogenesis neuropsychiatric diseases

"Early telencephalic development involves patterning of the distinct regions and fate specification of the neural stem cells (NSCs). These processes, mainly characterized in rodents, remain elusive in primates and thus our understanding of conserved and species-specific features. Here, we profiled 761,529 single-cell transcriptomes from multiple regions of the prenatal macaque telencephalon. We defined the molecular programs of the early organizing centers and their cross-talk with NSCs, finding primate-biased signaling implicating GALP in the antero-ventral telencephalon. Regional transcriptomic divergences were evident along the fronto-temporal axis at early states of neocortical NSC progression and in neurons and astrocytes, more than in intermediate transitions. Finally, we show that neuropsychiatric disease- and brain cancer-risk genes have putative early roles in the telencephalic organizersÕ activity and NSC progression."

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Access
open
License
CC BY 4.0

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  • Download BDBag https://data.nemoarchive.org/publication_release/sestan_sc_nhp_dev.tgz 82 files 1,825.39 GB
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Anatomical Regions

No anatomical region listed for Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon collection.

Taxa

rhesus macaque

Projects this collection belongs to

  • nemo:std-puehgtp
    "Developmental cell census of human, non-human primate and pig brain"

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Child collections

  • nemo:dat-yq75kip
    Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon: Raw data

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Documentation & resources