Identifier Results

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Identifier nemo:dat-fjx1jbr
Dataset Name Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon
Version NA
Release Date NA
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Dataset Collection URL
Description Early telencephalic development involves patterning of the distinct regions and fate specification of the neural stem cells (NSCs). These processes, mainly characterized in rodents, remain elusive in primates and thus our understanding of conserved and species-specific features. Here, we profiled 761,529 single-cell transcriptomes from multiple regions of the prenatal macaque telencephalon. We defined the molecular programs of the early organizing centers and their cross-talk with NSCs, finding primate-biased signaling implicating GALP in the antero-ventral telencephalon. Regional transcriptomic divergences were evident along the fronto-temporal axis at early states of neocortical NSC progression and in neurons and astrocytes, more than in intermediate transitions. Finally, we show that neuropsychiatric disease- and brain cancer-risk genes have putative early roles in the telencephalic organizers’ activity and NSC progression.
Keywords neural stem cell; radial glial cell; patterning center; telencephalic organizer; GALP; development; evolution; neocortex; neurogenesis; gliogenesis; neuropsychiatric diseases
Total Files in Collection 82
Total Size in Collection (in GB) 1822.5
Authors Nicola Micali, Shaojie Ma, Mingfeng Li, Suel-Kee Kim, Xoel Mato-Blanco, Suvimal Kumar Sindhu, Jon I. Arellano, Tianliuyun Gao, Mikihito Shibata, Kevin T. Gobeske, Alvaro Duque, Gabriel Santpere, Nenad Sestan, Pasko Rakic
Organization Yale School of Medicine
Contact Person Shaojie Ma; Kevin T. Gobeske; Nenad Sestan; Pasko Rakic
Contact E-Mail;;;
External Identifier NA
Grant Name Instituto de Salud Carlos III Spain and European Social Fund grant MS20/00064; grant PID2019-104700GA-I00 funded by /AEI/10.13039/501100011033; grant 202230-30 from Fundació La Marató de TV3; National Institutes of Health grant R01HG010898-01; National Institutes of Health grants U01MH124619,MH122678,HG010898,MH116488 and DA053628; National Institutes of Health NIDA Merit Award DA023999
Consortium BICCN
Data Repository NeMO
Data Repository RRID RRID:SCR_016152
Data License CC BY 4.0
Data Access NA
Community Standards
Study Organism rhesus macaque
Protocol ID NA
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Description Raw data associated with the following publication: Micali et al. 2023. Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Science. DOI: 10.1126/science.adf3786
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