| Field |
Value |
| Identifier |
nemo:dat-oiif74w |
| Dataset Name |
A multi-omic atlas reveals cellular dynamics in the developing human neocortex |
| Version |
NA |
| Release Date |
NA |
| DOI |
NA |
| Source Data URL |
https://data.nemoarchive.org/biccn/grant/u01_devhu/kriegstein/multimodal/sncell/ |
| Dataset Collection URL |
https://data.nemoarchive.org/publication_release/LiWang-Kriegstein_scMultiome_2024.tgz |
| Description |
The development of the human neocortex is highly dynamic and involves complex cellular trajectories controlled by cell-type-specific gene regulation. Here, we collected paired single-cell chromatin accessibility and transcriptome data from 38 human tissue samples from the prefrontal cortex and primary visual cortex. These samples span five main developmental stages, ranging from the first trimester to adolescence. This atlas has allowed us to catalog cell type-, age-, and area-specific gene regulatory networks and to infer the molecular logic underlying neural differentiation. |
| Keywords |
neocortex, multiome, human, development |
| Total Files in Collection |
988 |
| Total Size in Collection (in GB) |
1744.9 |
| Authors |
Li Wang, Cheng Wang, Jingjing Li, Arnold Kriegstein |
| Organization |
University of California, San Francisco |
| Contact Person |
Li Wang |
| Contact E-Mail |
li.wang@ucsf.edu |
| External Identifier |
https://doi.org/10.1101/2024.01.16.575956 |
| Grant Name |
SFARI Research Grant 697827, U01MH114825, R35NS097305, K99MH131832 |
| Consortium |
BICCN |
| Data Repository |
NeMO |
| Data Repository RRID |
RRID:SCR_016152 |
| Data License |
Public data available under CC BY 4.0; controlled access data subject to data use certification |
| Data Access |
https://biccn.org/terms-of-use |
| Community Standards |
https://biccn.org/standards |
| Study Organism |
human |
| Protocol ID |
dx.doi.org/10.17504/protocols.io.eq2lyj3nplx9/v1 |
