A multi-omic atlas reveals cellular dynamics in the developing human neocortex

Collection Type

Dynamic

Keywords

neocortex multiome human development

"The development of the human neocortex is highly dynamic and involves complex cellular trajectories controlled by cell-type-specific gene regulation. Here, we collected paired single-cell chromatin accessibility and transcriptome data from 38 human tissue samples from the prefrontal cortex and primary visual cortex. These samples span five main developmental stages, ranging from the first trimester to adolescence. This atlas has allowed us to catalog cell type-, age-, and area-specific gene regulatory networks and to infer the molecular logic underlying neural differentiation."

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Access: open
License: Public data available under CC BY 4.0; controlled access data subject to data use certification

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Download BDBag https://data.nemoarchive.org/publication_release/LiWang-Kriegstein_scMultiome_2024.tgz 988 files 1,744.94 GB

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Browse HTTP server https://data.nemoarchive.org/biccn/grant/u01_devhu/kriegstein/multimodal/sncell/ 988 files 1,744.94 GB

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No anatomical region listed for A multi-omic atlas reveals cellular dynamics in the developing human neocortex collection.

Taxa

human

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Child collections

nemo:dat-0j8ee1v

A multi-omic atlas reveals cellular dynamics in the developing human neocortex: Raw_ATACseq
nemo:dat-tht69sc

A multi-omic atlas reveals cellular dynamics in the developing human neocortex: Raw_RNAseq
nemo:dat-mbkuyiy

A multi-omic atlas reveals cellular dynamics in the developing human neocortex: Analysis

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Contributors

Li Wang University of California, San Francisco

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