Transcriptomic characterization of the developing human hippocampus

Program
bican
Collection Type
Dynamic
Keywords
hippocampus dentate gyrus radial glia cell neurogenesis transcriptome Basal Ganglia

"We generated a single-cell RNA sequencing dataset using the 10x Genomics platform, yielding approximately 30,000 high-quality nuclei after filtering. Developing human hippocampal tissue was profiled across nine donors spanning early gestation, infancy, and adulthood (gestational weeks 15, 18, 19, 21, and 23; postnatal 2 weeks, 4 months, and 7 months; and an adult sample aged 38 years). Following preprocessing and quality control, cell types were manually curated based on canonical markers. Pseudotime analysis identified five transcriptionally distinct radial glial cell subtypes within the human hippocampus. Comprehensive metadata, including cell-type annotations, donor demographic information, and batch identifiers, accompanies the dataset."

Data citation
No data citation listed
Funding agency
NIMH
Grant numbers
U01MH130995
Access
open
License
No license listed

Download URLs

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Anatomical Regions

  • hippocampus (hippocampal formation)

Taxa

human

Projects this collection belongs to

  • nemo:prj-vwtwc3r
    Spatiotemporal epigenomic and chromosomal architectural cell atlas of developing human brains

Assays, Modalities & Techniques

Assays
transcriptome spatial transcriptome
Modalities
transcriptome multimodal
Techniques
10x chromium 3' v3 sequencing 10X genomics multiome;rnaseq

Child collections

No child collections listed for Transcriptomic characterization of the developing human hippocampus collection.

Parent collections

Associated publications

No publications linked yet.

URL Protocols

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Contributors

  • Oier Pastor-Alonso No affiliation listed 0000-0001-8075-1768
  • Matthew Heffel No affiliation listed
  • Susana Gonzalez No affiliation listed
  • Mohammad Baig No affiliation listed
Show 15 more contributors
  • Selina Li No affiliation listed
  • Julia Chu No affiliation listed
  • Maria Isabel Torres No affiliation listed
  • Hannah Lambing No affiliation listed
  • Andrew Cheng No affiliation listed
  • Matthew Varughese No affiliation listed
  • Jaeyeon Kim No affiliation listed
  • Jasmine Harris No affiliation listed
  • Jessica Le No affiliation listed
  • Eric Huang No affiliation listed
  • Arturo Alvarez-Buylla No affiliation listed
  • Jesse Gomez No affiliation listed
  • Jose Manuel Garcia Verdugo No affiliation listed
  • Chongyuan Luo University of California, Los Angeles 0000-0002-8541-0695
  • Mercedes F Paredes No affiliation listed

Cross-archive links

No cross-archive links listed for this collection.

Documentation & resources